Which data most reflects fatigue in a patient with metastatic brain cancer?

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Fatigue is best understood by how it changes what the patient can do day to day. In metastatic brain cancer, the clearest sign of fatigue is a reduced ability to perform usual activities, or decreased functional status. A note about taking several naps shows a behavior associated with fatigue, and anemia values can contribute to fatigue, but they don’t measure how fatigue limits functioning. The drop in functional status directly reflects the impact of fatigue on the patient’s life, so it’s the most informative data in this context.